I have been driving my Murano for approx 5 months. It drives and handles very well. I am 6' 3" tall and have plenty of head and leg room. With the CVT transmission you don't feel any shifting. My wife likes the dual climate controls.
The best part of the Murano is the smooth ride.
The S model only comes with a four speaker stereo system. They should give six speakers like the SL and SE.