2003 Mercedes-Benz M-Class ML350 AWD 4dr SUV (3.7L 6cyl 5A)
I drive this thing +175 miles a day, 4 to 5 days a week under all conditions and on every type of road way and I really enjoy the car. It has enough room for passengers to be comfortable, but is much more comfy for me than my last 2000 ML320. For a car to stand up to what I put it through and keep going with little to no maintenance is very pleasing. A great buy and I don't even care that I have to reach over 6 inches to adjust the radio instead of the steering wheel.
Bose stereo, handling (in weather and on interstate), engine and options.
Gas mileage is a simple suggestion, but I guess you can get a Focus if that's your main concern.