Having owned several Mercedes, including two prior Es, I find this latest generation to be a winner. I'm barely 800 miles into this car and I couldn't be happier with the experience. All the expected MB touches like fit and finish are superior. Paint is flawless. The ride is appropriately comfortable without being soft. The ergonomics of the cockpit are the best I've driven lately.
I find the Command interface to be superior. The navigation system is the best I've seen and easily beats the version in my Audi Q7. The shifter on the steering column took some getting used to, however glad to have if off the center console.
Speedometer: utterly unreadable in daylight driving. The 3/4" needle is white on a grey background. I find I need to keep the center TFT screen on mph to know my speed at a glance.