2010 Mercedes-Benz E-Class E350 4dr Sedan (3.5L 6cyl 7A)
This is my third E-class (1997, 2003, and 2010), and it's the best of the bunch in most areas. The transmission is a major step up, and the ride and steering are even better than before. The "Command" system requires a steep learning curve, but it is all you could ask for in terms of options. I'm not sure what the mileage will be after some long trips, but in the 1600 miles I've driven so far (mostly around town) it's 21.7, which is not bad but not quite up to the 23.5 that I got with the 2003 (overall for 107,000 miles). I hope the reliability improves: it was substandard on the two previous models, which was my only major complaint. Outstanding safety features make up for this, however
Ride, handling, styling, performance. Also, the Sport package extras are nice.
(1) The instrument panel displays wash out in strong sunlight and are practically impossible to see. Great at night, however. (2) The rocker panel below the front door sticks out way too far, and it's hard to exit the car without brushing against it and picking up dirt on your trouser legs.