I've way more issues with the '06 than my old E55 (2002 W210 E55) although, yes, the 2006 is a rocketship in comparison. MB has lost the "tank like" build quality of the older cars, and doesn't seem to care what the buyer endures as far as problems, but the car is scary fast, and is still the best 4 door hot rod money can buy. Get the build quality up to Lexus standards, and there will be no room for BMW in this market.
Amounts of torque, HP.
Fix the dealer attitudes, and little electrical gremlins.