I got this car in Feb 2005 - one of the first 2006 E350s to come off the boat in America. I had held off choosing between the 2005 model year E320 and E500 because I felt that there must be a better solution with more horsepower than the E320 but less cost than the E500. Sure enough, waiting one model year was worth it, because the E350 hits that sweet spot right between the old E320 and the E500.
Built-in phone system that downloads phone book to dash computer while, great sound system, glass roof in both front and back of cabin. Pressing the gas pedal is quite fun as well.
Smoother shifting from the 4MATIC transmission would be nice - sometimes it feels just a wee bit clunky.