2006 Mercedes-Benz E-Class E350 4dr Sedan (3.5L 6cyl 7A)
It may sound cliche (and downright corney) but the new Mercedes E350 *IS* the most comfortable, well-built and safety minded car in its class. I have owned a BMW 325 and an Infinity I-class and this vehicle blows away the competition. The ride cannot be described. Quiet, fast when required and a feeling of complete safety. The vehicle is very responsive without feeling mushy like many of the Japanese competitors. Try one!
The navigation/sound system are very easy to use. The sound system is excellent.
I have a dual-glass moonroof. I would make the rear moon-roof retractable.