2005 Mercedes-Benz E-Class E500 Rwd 4dr Sedan (5.0L 8cyl 7A)
I love this car. After owning it for 2.5 years, it's been in the shop once, for an oil change. Absolutely nothing has gone wrong. A very fast car with just the right balance between race car performance/handling and luxury tourist. Gas mileage on the highway going 75 mph with A/C on around 27 mpg and city around 16 mpg which is amazing considering the large fast engine.
Mileage, speed, looks and quality of both the exterior and interior.
Placement of the cruise control stalk (right next to the turn signal stalk), high cost of the E500 engine, funky climate controls that have a hard time maintaining the correct interior temp when set on auto. Impossible to brake smoothly, electronic brakes grab and pulse when stopping.