2001 Mercedes-Benz E-Class E320 Rwd 4dr Sedan (3.2L 6cyl 5A)
My family loves this car. We drive 700 miles a day when we travel, which is frequently, and we never feel tired afterwards. We are all the way up to 137K miles now and really it feels as solid as it did at 40K. The fuel mileage is amazing. We get 29 mpg on the road and average 26. Everybody looks at it admiringly, even though now it is 7 years old. We have had to make some repairs, but if you shop around and find a reasonable mechanic it really isn't much more expensive than other cars.
Ride, acceleration, gas mileage, looks, safety. Especially safety.
CD player in dash instead of trunk, larger trunk, make the exterior look a bit more expensive.