I've owned an AWD 450H for about 2 months now Overall I'm impressed. Well built, supple ride, handles well, and quiet...all things you'd expect from a Lexus. So far I'm averaging 27.5 MPG which is actually fairly close to the EPA estimate. The math doesn't pay for the hybrid though. I recommend it if you want to be eco friendly, but if it is just a straight $ decision, purchase the 350.
The cooled seats, interior trim, and HUD.
The power ports are located in the bottom of the console and are VERY inconvenient. Not enough of them and a pain to use. The NAV system requires XM subscription for traffic updates. Back seats don't fold flat.