I've owned an AWD 450H for about 2 months now Overall I'm impressed. Well built, supple ride, handles well, and quiet...all things you'd expect from a Lexus. So far I'm averaging 27.5 MPG which is actually fairly close to the EPA estimate. The math doesn't pay for the hybrid though. I recommend it if you want to be eco friendly, but if it is just a straight $ decision, purchase the 350.
The cooled seats, interior trim, and HUD.
The power ports are located in the bottom of the console and are VERY inconvenient. Not enough of them and a pain to use. The NAV system requires XM subscription for traffic updates. Back seats don't fold flat.
† Edmunds.com received the highest numerical score in the proprietary J.D. Power 2014 Third-Party Automotive Website Evaluation Study℠. Results based on responses from 3,381 responses, measuring 14 companies and measures third-party automotive website usefulness among new and used vehicle shoppers. Proprietary study results are based on experiences and perceptions of owners surveyed from January 2014. Your experiences may vary. Visit jdpower.com.