Had my previous '03 RX in for an oil change and drove the 2010 RX350. I went ahead and placed the 1st order with money and got the exact car I wanted on the 1st delivery. What a technological marvel !!! I truly don't believe there is 'any' competition in it's price class with this much performance, luxury, safety, features, and economy. I plan on keeping this car till the batteries fail, probably about 10 years.
There is no belt being pulled by the engine, and that's a big help in the economy. A/C, Pwr St, and throttle are all electric. Valves driven internally with cam chains so maintenance is low. The new NAV system is state of the art but you must study the manual to conquer it.
I miss little things like the coin box, the elastic pockets on the back of the front seats rather than the ones they have now. Basically little items, not deal breakers. Nearing 5k in miles toward the 1st oil change and everything is working as designed. I love it. Nothing terribly negative.