Our first hybrid and first SUV; had it 7 years (+105k miles), in both city and rural areas (dirt roads). Our 400h performs consistently well, even in blizzards and icy/snowy conditions in hilly New England winters. Super comfortable - I'm 5'5" (and been pregnant twice with this car), hubby is 6' - we both love it. Low maintenance - our only major expenses (besides one new set of tires) have been replacing the battery and brakes. Note to new parents: larger, rear-facing car seats fit best on the passenger side to give taller drivers enough legroom (I fit; hubby doesn't). By far the best SUV I've ever driven - and the hybrid/gas mileage factor is the icing on the cake!
Our 400h averages 27-28mpg on hilly country roads, w/some highways. Comfy, quiet, smooth, luxurious ride. No road noise; plenty of power to get up steep hills and/or accelerate into highway traffic easily (far better than our Prius). Love the heated leather seats, nav system, 6-disc CD player, hands-free bluetooth and moonroof. Cargo space fits two 70-80lb dogs with ease and 40-20-20 seat split provides great flexibility; auto-liftgate in back helpful when juggling kids and bags. Second row fits larger car seats for infants/toddlers (e.g., Chicco Key Fit 30, Britax Advocate 70 CS Convertible/rear-facing) without sacrificing leg room for front passengers (but too crowded for driver's side).
Slightly more cargo space and a slightly wider second row (or the option of a third row) would be great, to fit more than two car seats - or more dogs.