I have a 2006 RX400h AWD with 53,000 miles on it. I do 80% of my driving in the Seattle Bellevue area and 20% on interstates (mostly between Seattle and Portland). Depending on the season, I get 22-25 mpg in combined city and highway driving and 28-31 mpg on the Interstate. I consistently get 30-31 mpg between Seattle and Portland. This is my 3rd RX and am waiting to see the 2009/10 model. I haven't had any major problems and service at the manufactures recommend intervals.
Auto rear door, planetary gear transmission, and extra MPG compared to my two other RXs.
MPG are greatly reduced on short trips because the engine has to run until the catalytic converter is warmed up. Another method of heating the converter would increase the MPG. An MP3 connection would be appreciated.