I have have been extremely pleased with this SUV so far. Very comfortable interior design (still getting use to the mouse for navigation), excellent safety features, and the car just feels extremely well built and solid. Don't expect a BMW or Audi-like drive with sports suspension tuning etc., but it is quiet, sturdy, and nimble enough to handle most road situations. The first recommended scheduled maintenance has been changed to 5k (not 1k). I find the seats comfortable. At close to 2k miles so far and not one single problem.
Navigation system is great and easy-to-use (tons better than Mercedes, BMW and Audi), solid ride, Lexus safety features, comfortable interior design, great sound system, too many to list
ipod adaptor is a joke (can't toggle through playlists/artists), at least one power outlet should be more accessible, lack of illumination for overhead buttons, expected better fuel mileage