Currently own a BMW sedan. Looked at 2011 BMW X5 for our second car. Great driving machine, but expensive when add up options for what it is. Looked at RX350 and though not nearly as high performing, provides a higher level of comfort and luxury feel, and quality is great like BMW. Have been driving it for a month now, and I am very impressed. Not nearly as fun to drive as a BMW, but I believe it is an all around great choice and solid value. For those who like the rear lights on the old RX 350, I find the new design much more appealing. Overall look is less round and top heavy, and more sporty. Eye of the beholder.
None that I can think of yet. Road feel is good (and I understand improved), but could be better.