Moved up from an '04 RX. After only a few days driving (170 on the ODO) pleased w/ improved suspension, lower road noise and more positive - less slushy feeling in transmission. There is a slight rattle coming from under the dash. I hope it can be silenced in the 1k inspection. Typical Japanese overkill in the electronics - many features I'll never use and can be confusing. The NAV manual is 5/8" thick. Gadgeteers will love it - umpteen variations on the same function. Mouse concept for NAV, climate, audio etc.is great but can distract from driving. Quality of materials, fit and finish up to high Lexus standards. So far getting 17.4 mpg avg in city driving on first tank of gas.
NAV, comfort - improved suspension, right size and balance of cargo space, power and economy, quality of materials design and assembly. Satellite radio nice but won't pay for service.
Awkward place for plug in for electrical attachments, not enough cubby spaces for small stuff in front - driver's or passenger's side.