In the 4 months I've owned the RX350 it has been from Ohio to California and back, with several 700 mile days in the driving mix. Fuel economy runs around 23-24 mpg at 80 mph+ cruising speeds. It's extremely comfortable, with nice performance, being very brisk off the line, but at speed shows its weight and aerodynamic drag. The car (suv?) is very solid, and most interior features are well thought out. It feels large inside, but I came out of a restaurant at lunch to find it parked between two Suburbans; then it looked tiny! Brakes are very good, but the steering is a bit numb and the suspension is soft with resulting "average" handling. Not a single problem at 6000 miles. Great vehicle
Comfort, balance of fuel economy and power, brakes, interior room, overall efficiency of package, reliability.
Handling and steering could be a little sharper. Like most cars, the control layout is OK once you learn it, but it would be nice to have a little standardization for those of us with too many vehicles.