My first Lexus (1998 ES 300) I drove 164,000 miles absolutly no problems. The Lexus 2007 RX 350 that replace it now has 27,850 and absolutly no problems. There is a pattern here. The quality, fit and finish are 1st rate. Yes, it costs a little more in the initial purchase price but you get it back many times over in reliability, comfort and safety. I am an engineer by profession and I am really picky.
How well the electronic systems are integrated. Bluetooth phone, sat radio, wipers, head lights, etc., it all works all the time all together.
When the car is moving you cannot program the GPS which is a real pain, especially if your caught in traffic and your looking for alternatives routes.