I had a RX 300 for 7 yrs 152k miles, never had a repair. My friend totaled it. I wanted a sports sedan w/manual tranny. I looked at the IS 250, BMW 325-330, Infiniti G35 & Acura TL. My earlier experience w/lexus was outstanding so I thought this would be a no brainer. It has less performance than the competing models, however it is a perfect car for me. Plenty of power, so quiet, wonderful seat and driving position. It handles really well and the 6 spd is a lot of fun.
Driving position, 6 spd, stereo rocks w/iPod integration, steering wheel controls, ac/heated seats trunk pass threw is great. Gas mileage has been 27 on average per tank.
Make the IS 250 6spd AWD. Back seat is small. Different size front vs rear tires is not ideal.