HS250H base model: The car is excellent but at first the fuel economy was not that great with about 32-34 mpg overall. Last February Lexus requested an appointment with a technician who would "work" on the car at my home. Two guys show up with a laptop and sit in the car for about an hour. They connect to the car's computer system and formatted (erased) most of the car's hard drives and loaded new programs. Diving the car afterward was like driving a different car. The engine was tuned better to the driving dynamics and the the fuel economy jumped by 5 mpg. I get 42 mpg on flat highways, 38 - 40 on mountain roads, and 36 - 40 in stop & go driving. It's a great experience.
Fuel economy, comfortable seats, easy to read instrument display, excellent radio, excellent climate system, roomy interior for average size adults.
This goes for all hybrids - more power when needed. The car can be sluggish at times on hilly roads depending on the grade of the road. The power driving mode does help. You can forget you are diving a hybrid on flatter roads.