We had a tough time deciding between this and the ML. In the end, Lexus reliability and interior finish were what sold us. For the money the interior of the Lexus felt more polished (totally a personal choice here) than the M. Although the GX does have a tape deck, which definitely is dated! Seats are comfortable and layout of dash made sense. Also, the crossover drive feel of the ML, RX and MDX was unappealing to us. The GX works well for male & female but the Xovers felt very girly. After 2 months of use we really are pleased with it. Ride is comfortable around town as well as freeway, fuel economy as with others in this class is OK. Fits 2 car seats easily.
3rd row is great for short trips with more adults or carpool. Nice to have. Seats are really comfortable. Overall drive and ride is very smooth and quiet.
Not crazy about the side swinging rear door, but am used to it, and where we live we never parallel park so it isn't an issue.