This is an all-around fantastic car! It's amazingly smooth, even over large bumps, pot holes and medians. The navigation is very user-friendly, I learned it in less than a day. We bought ours with 50,000 miles on it. I would never blink at purchasing a high-milage Lexus (not that 50K is high), they run forever. We haven't had any problems with ours, except for replacing the drive shaft (a problem they are aware of with these cars which is covered by the manufacturer, totally no cost to us).
I love the audio controls on the steering wheel and the overall handling. Super smooth ride.