Have been driving my GS 350 for almost 5 months now. Really love driving it and sometimes do not want to get out! Having driven the previous GS 300, this is a completely different animal. Is it perfect - no, not really. However, no car is perfect. Lexus has their shortcomings, even in a $50k vehicle, however, they do what they can to make things right most of the time. I am very happy with my choice and would purchase it again in a heartbeat.
Pushbutton start! How did I ever live without it? Bluetooth phone integration for handsfree while driving works very well also. Driving experience - it's no BMW, but it is fun to drive. You don't feel tired after driving 200 miles in one shot.
Bigger trunk, nav system that allows input while car is in motion, better gas mileage (or change window sticker to reflect truth) - I tend to average about 18 MPG in the city driving very passively.