Based on the opinion of a friend, purchased a 2008 ES-350 w/ 56k miles from Lexus dealer. Immediately experienced transmission shift flares, abrupt downshifts. Software update didn't fix it, transmission was replaced. Other issues not yet addressed: soft engine knock (piston slap?), timing chain rattles briefly when engine not started for several days, plenty of interior rattles, and of course paint chipping. While baffled that a car costing over $40k new would exhibit these technical issues at av'g miles, I must say the dealer service (Sewell in Dallas) has been exemplary so far.
Smooth ride, good fuel economy, lack of wind noise.
General build quality, interior appointments quality, durability of exterior finish, powertrain integrity, etc., etc.
Build and deliver a car that is substantially more than a Camry with better insulation.