Bought my ES300 at 83,000 miles. No troubles, absolutely no troubles at all. Never been to the shop at all except for regular maintenance oil changes. At speeds above 75, wind noise gets appreciable higher through the window. The car has lots of pep only when floored. The tranny thinks for about a second before shifting and then the car flies. A very smooth ride and smooth steering. Absolutely disgusting cup holders. I have given up on the floor mat after numerous spills. There is a noticeable body roll during cornering at high speeds, but that's due to the soft suspension bug - again the ride is magnificently soft. If you are looking for a soft, plush, trouble free ride. This is not a sports car.
Smooth ride. Ok music system. Nice seats.
Horrible cup holders. Don't trust the cup holders to hold your drinks. You WILL have a spill. Tranny pauses sometimes. Slight wind noise at high speeds.