S2000 is almost 10 year old now; and still; I would not change it with a brand new Z4, Miata, Solstice, Sky and even a Boxster. Unlike most cars, S2000 is a purpose built driving machine. Engine, transmission, and chassis is not shared by any other model. Engine is small, light and powerful. Best manual transmission available in ANY car: short, precise, excellent feel. Chassis is so stiff, the rear tire was also raised when I was jacking up the front! The engine is located completely behind the front axles, and the rear is a tad heavier than the front. The steering response is unreal; immediate response to any steering input. S2000 is designed to give you the utmost driving satisfaction...
Engine, transmission, interior ergonomics and controls, chassis, handling... Top goes down or up in 6 seconds. Ample trunk space. Honda reliability. Leg room: I am 6'1" and fits me like a glove. S2000 makes me smile each time I get in, like no other luxury feature can.
Absolutely none. S2000 has a very well defined goal, and it accomplishes it extremely well. Get a Z4 if you want more luxury and a quiet ride. However, with the S2000, you will get better handling and quicker responses.