Replaced a 7-year-old Sienna (118K miles). Very happy with the Odyssey so far (6 weeks). Roomy, comfortable, good ergonomics. Passed up DVD and Navi due to out-of-line pricing--given how these have plummeted in price as aftermarket add-ons.
Ergonomics. XM. Handling. Ride. Interior space/flexibility.
Floor mats have old fashioned metal snaps to hold them down... not terribly effective (or difficult to snap).