My wife and I picked out a 2008 Honda Odyssey EX-L 5 1/2 years ago with 20 miles on it. We now have just over 73,000 on the vehicle, and we are even more happy now than when we purchased the van because nothing has gone wrong.
There has been several recalls such as the brakes, the transmission reprogramming, and cabin noise, but Honda was pretty good (once they acknowledged the issues) at taking care of them.
With a fully loaded van (family/cargo) on a flat road I can get 27/28 mpg easily. In town she avg. 18-20 depending on how much a/c we are using.
As for us we have had a good experience.