We bought the van new and after about 13 months noticed a noise in the transmission. The local dealer where we purchased the van replaced the transmission without a problem under warranty. We now have 158,000 miles and no problems. The van has served us well despite the minor issues stated in other posts such as sticky sliding doors in cold, wet weather and very hot weather. A light coating of silicone on the weatherstripping has always helped. The only other issue we have had is the remote headphones for the entertainment system stopped working at about 125,000 miles. Other than these issues we have been pleased with the van.
Comfortable and spacious cabin, fold down third seat, good visibility, no blind spots, strong acceleration.
Honda should acknowledge the transmission issues and provide an extended warranty similar to how Nissan handled their Murano transmission problems.