After having a troublefree Honda 1990 Accord for 240,000 miles, my expectations were high for the Odyssey. I was initially worried about 2 things: Honda bragged that the Odyssey was built on an Accord chassis (but weighs half-again as much!), and the automatic side doors (always takes a few years for any new mechanical device to get the bugs out). Sure enough: balky sliding doors that frequently freeze shut in wet, freezing weather. Several $1000+ repairs: shocks, fuel system, and now at 132,000 miles,transmission. Presumably because they have so many going out, they recently bumped the transmission remanufactured price by about $1000 (making money off their poor workmanship?).
Easily reconfigured interior, engine itself still solid, huge carrying capacity, very good visibility.
Improve reliability of automatic sliding doors and seal them so that don't freeze shut. Heavier duty shock system. Greater reliability of automatic transmission and fuel injection system. Better rear wiper. All seats starting to have some play.