I have three cars with over 120,000 miles and the Honda Odyssey has been the most expensive to maintain in the past two years; however, it has been the car we have put the most miles on. We recently replaced the alternator and it seems to eat through brake pads, but no major major problems (like tranny). Many of our repairs in the past year are first time ever fixes. Very nice van still that we will continue to drive.
Room and how well Honda uses space. We loan out our van to family members quite a bit.
I wouldn't mind some of the updated features but we have the EX-L and it has survived time and a lot of miles very well.