Bought it new to replace a Plymouth Voyager. The Odyssey ranks right down there with Chrysler mini-vans in terms of reliability; radio electrically shorted at 40,000 miles, transmission at 65,000 miles, front wheel bearing at 70,000 miles, motor mounts at 95,000 miles, passenger door window glide at 105,000 miles (had a cold 600 mile drive home without a passenger window in January as it broke on the week end), driver side window glide at 110,000 miles. Honda paid for the transmission and I PAID for everything else. Total for other items = approximately $2000. Electronic doors "hang" at times but at least they work for the most part. A very nice van IF you don't mind the repair bills.
Mileage in town (16 mpg) is not bad for a large mini-van. On the road it gets between 23 and 28 mpg. Has lots of power. Has lots of interior space for traveling and is quite comfortable.