Purchased Odyssey new in April 2000. Had a '92 Chrysler minivan previously which was the most unreliable vehicle ever. Have 4 kids and needed something large. Now has 113,000 miles, extremely reliable (routine maintenance only) except for transmission. Replaced transmission last year at 105,000 miles. Honda split the cost based on extended warranty for transmission. Sliding doors stick in wet weather. 16-18 MPG city, 22-25 MPG highway at 70-75 MPH. Reasonable for a heavy vehicle. Still solid with no squeaks or rattles. Don't use to too often anymore but it runs great. Own three other Hondas and Odyssey has been just as reliable.
Panoramic view out front windows. Crisp handling for its size. Room for a large family, dog and luggage for a long trip. Excellent A/C on hot days.
Sliding doors stick. Acceleration adequate which gets leisurely with a heavy load. Wind noise on highway.