We bought our 2000 Odyssey in 2004 with 93,000 miles. We just replaced the original transmission with a nicely rebuilt one. I love this van! Drives nicely, looks great, gets good mileage (avg. 21 mpg) for a van. For the wear and tear we have put on it, 3 kids, 6 dogs, numerous road trips, it has performed admirably.
Love my Navigation system, upgraded the DVD. Love the cargo room, ease of stowing rear seats and removal of 2nd row.
Honda should really have put more thought into the transmission, the clutch plates need more lubrication grooves, they should use synthetic ATF, and a cooler and inline filter should be standard! The sliding doors need more durable rollers! Other than that, I have no suggestions.