We purchased new in Feb. 2006. Since, we have driven from Washington, DC, to Fairbanks, Alaska and have driven it around Alaska for almost 2 years. Let's just say that driving conditions in Alaska are less than ideal: it's Winter 8 months of the year, and most roads outside Anchorage and Fairbanks are not paved. Despite the fact that our CR/V has been less than pampered, we have had zero problems. It was also the least expensive in its class, considering that many of its standard features are options on the RAV-4.
Reliability, reliability, reliability. Oh, and also handling, fuel economy, and price.