Bought this car new in 2000. I had owned Honda cars in the past and trusted them to be reliable. As of today (5 May 08), my trusty CR-V has nearly 150,000 mile on it and still runs perfectly. All I have done is change all the fluids regularly and drive it gently. I changed the timing belt at 100K, but other than that, it has never been in the shop for anything. Still has the original brakes. Paint is still in good shape, too. I like the fabric seats. Tons of space in the rear. Easy to clean. I'd buy another in a heartbeat, but I don't think this one will ever wear out.
Good sound system. rear seats very easy to fold down and that leaves LOTS of cargo space. Lots of ground clearance (easy to change my own oil).
Engine needs a few (actually, lots more) more pony's (I think that has been addressed since 2000, though). The body seems to be made of tin foil, so try to avoid hail storms. Move the oil filter to the front of the engine.