No major problems (yet). Mine has the small v8 with tow package so it is slow going up hills with a trailer. At 100k miles transmission is starting to have rough shifts when cold. Haven't done much towing or city driving and it has a cooler as part of the tow package. Original Goodyear tires lasted 92k miles! Still on original disk brake pads at 108k miles. Best truck I have owned.
Lariat interior and controls are excellent. At the time they were better than many upscale cars. Fit and finish, reliability very good.
Power and fuel economy need improvement. Ride is harsh, even for a truck.