I have a 2001 F-150 4.2L 6-cyl. My dad bought it in 2002 with about 15,000 miles on it. He ran it for 12 years loaded with all of his work equipment, which was a pretty heavy load. When I got it about 2 months ago it had 285,000 miles on it. As of now it has almost 289,000 miles on it and I'm confident I can get it to 350,000 miles easy. Original engine and tranny. The only things that have been replaced is the rotors, oil pump, drive shaft, and basic maintenance. Last month I ran it into a guide rail and other than a broken headlight and a bent bumper it was fine. I rely on this truck to get me to work and college on a daily basis. Very sturdy and reliable.
Low maintenance, definetly built Ford tough, pretty good mpg for an older truck.