I bought the 2001 XLT, 2WD, 4.2, 5 speed in 2004. It's now 2016, and this truck still runs like a clock at 175k miles. The only thing I have ever done is change the oil, and air filter, plus other regular maintenance. This truck owes me nothing, and has paid for itself. I did put new plugs in it at around 100k , new ball joints and all tie rod ends in at around 150k. I get 15mpg city., and 19mpg on the highway. It is starting to look old-school, so, I priced new trucks, but they offer the same mileage. I have decided to keep what I have paid-off years ago, and only costs me fuel and nickel-and-dime maintenance. The engine and 5speed manual tranny sound like they are new, still. The headlights are starting to fog over after 16 years, so I'm going to have to spend $38 on a restore kit. I know that tomorrow I can jump in this truck and drive across the country, if I had to, and there would be no issues.
2001 4x4 5.4L purchased in 2001, traded in 2015 for new F-150. Never any problems. Normal repairs - brakes, battery...didn't need front axles until 2014. And that was with a 3" level kit. 14 years of perfection. I hope my 2015 F-150 does as well. That truck will problem give someone another 10 good years. A mechanic at the dealership where I traded it in actually purchased it.
I am the second owner of my truck. Bought at 100k miles in 2007 and now has 224k on odometer but closer to 230k miles since I have had over sized tires since purchased. Only had one problem, the master window switch went out, other than that just basic maintenance items. Motor and tranny are original (5.4L V8 & 4 Speed Auto). It's seen a lot of dirt and towing miles and she has performed flawlessly. It's comfortable to drive for long trips. If you keep up the basic maintenance, it'll keep you on the road. Couldn't ask for a better truck!
Comfortable to drive, nice rumble with Magnaflow exhaust, handles great in all weather conditions, bulletproof reliability.