Overall the Chevy S-10 has a solid engine with the Vortec V6. I will say I have the same problems as many others. Owned it for only a week (brand new with 53 miles) and the vanity mirror light stayed illuminated. ABS grinds. Mirror rattled loose. Tranny, clutch and catalytic converter went out at 50K. At some time still under warranty, wiper delay module went out. Now AC needs recharging every summer ($10 kit from Wal-Mart). Water pump, O2 sens., alternator, U-joints going out to be expected w/ high mileage. Check engine light stays on now with 135,700 with no other indications of mechanical problems. With regular maintenance, engine has no problem. Probably drive it until wheels fall off.
Looks sharp in black with tinted windows. Fun to drive with V6 and 5 speed manual. Not bad sound system for stock.
Make tranny and AC last as long as engine. Improve cab design for traffic light visibility while at rest in traffic light first position (for tall guys anyway). Design mirrors more rigidly. Improve gas mileage. With $3/gal. costs about $200 per month to operate. Go hydrogen or ethanol.