I've owned this Blazer since it waS new. About to turn over 100k miles. Just put on the 3rd set of tires. Not a lot of problems for a vehicle that old, but here is a list of problems I've had: Excessive paint chips since it was new, entire car repainted by dealer. 4WD is currently intermittent due to a vacuum problem. Leaking coolant. Replaced fuel sender. Hazard/brakelight/turn signal switch bad, intermittent brake lights. Replaced 3 speakers. Body molding coming off. Hoses to oil filter leaking. Climate control diverter is messed up, delayed in switching from floor to defrost, etc. probably due to vacuum leak. Never a MAJOR problem though.....
Leather seats, CD. Ease of oil change. 100k tune up.
Recall the turn signal switch, 4WD problem, Oil filter hoses, fuel sender. These are all common KNOWN problems with this vehicle.