Having had my 2012 TSX wagon for a month now, I am in a position to offer some feedback.
Gas mileage - keep it under 75mph on a flat road, and you will likely get 33 mpg.
City/suburan driving tends to run around 24-25 mpg.
Handling - very good.
Interior comfort - very good.
Performance - average to good, but not really sporting.
I do think that the wagon is overpriced, but then I also think that no new car is worth its sticker price.
Too much hard plastic and carpeting is more like mouse fur.
I bought it because every Honda product that I have owned has been very reliable.
Front seats, HID headlights, ELS sound system, navigation system.
The bluetooth phone link is not nearly as good as the bluetooth phone link available in the Crosstour.
My wife drives a Crosstour, so I ran a comparison.
For the price of an Acura, also expect interior materials to be better.