The 2004 Acura MDX Touring with Entertainment system has been one of the best vehicles I've owned in any class and absolutely the best SUV to date. Comfort, reliability, ergonomics and a lot better than average SUV handling hi-light its many features.
I would say reliability is paramount to me, handling and knowing that everything is going to work the first time when I need to use it.
The styling is a bit dated. But a new look is in store for 2008. Hopefully along with that new look will come better gas mileage, performance and braking as they all need improvement. Toyota has made greater progress in its SUV's with fuel economy than Acura where all models grave the good stuff.