I bought my CL-S w/Nav early (May 00) - and enjoyed having a car that wasn't too common,yet a real sleeper in performance (can run with some fast cars). I never had the transmission replaced that seemed so common - but watching it close (Acura stepped up and extended warr for all to 7 yrs/100K - a stand-up thing to do for a car company). The rest of the car's quality has been great - literally nothing has gone wrong. Had a squeaky sunroof and rear cargo lid - but both were fixed early in the car's life. I still ENJOY driving this car 6 1/2 years later.
The VTEC is great - the sound is fabulous north of 3700 RPM and the mileage is great if you stay off the pedal. I like this Nav system (circa 2000) better than most cars I've driven, including a Pioneer AVIC system I have in another car (big $$, 2005 tech.).
The rims are prone to scratching if you rub a curb. Acura should have launched this car with a 6 spd manual right away - might have helped it last longer.